5-AMINO-1-β-D-RIBOFURANOSYL-4-IMIDAZOLECARBOXAMIDE BY ALKALINE DEGRADATION FROM INOSINE
نویسندگان
چکیده
منابع مشابه
The Incorporation of Radiocarbon from 4-amino-5- Imidazolecarboxamide into the Purines of Tumor-bearing
The compound 4-amino-5-imidazolecarboxamide first was isolated by Stetten and Fox (1) from the medium of Escherichia coli which had been inhibited by sulfonamides. It was identified by Shive et al. (2) and recognized as a possible precursor of nucleic acid purines. Schulman et al. (3) showed that pigeon liver homogenates can convert 4-amino-5-imidazolecarboxamide to hypoxanthine, whereas the in...
متن کاملThe incorporation of radiocarbon from 4-amino-5-imidazolecarboxamide into the purines of tumor-bearing mice.
The compound 4-amino-5-imidazolecarboxamide first was isolated by Stetten and Fox (1) from the medium of Escherichia coli which had been inhibited by sulfonamides. It was identified by Shive et al. (2) and recognized as a possible precursor of nucleic acid purines. Schulman et al. (3) showed that pigeon liver homogenates can convert 4-amino-5-imidazolecarboxamide to hypoxanthine, whereas the in...
متن کاملInhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes.
5-Amino-4-imidazolecarboxamide riboside (AICAriboside; Z-riboside), the nucleotide corresponding to AICAribotide (AICAR or ZMP), an intermediate of the 'de novo' pathway of purine nucleotide biosynthesis, has been shown to inhibit gluconeogenesis in isolated rat hepatocytes [Vincent, Marangos, Gruber & Van den Berghe (1991) Diabetes 40, 1259-1266]. We now report that glycosis is also inhibited ...
متن کاملSynthesis of 5-amino-1-aryl-4-cyanoimidazoles from formamidines under solvent-free condition
The aryl-(Z)-N-[2-amino-1,2-dicyanovinyl]formamidine 2 cyclize in solvent-free conditions and in the presence of a base to give a 5-amino-1-aryl-4-cyanoimidazoles 3. Silica sulfuric acid as an efficient and reusable heterogeneous catalyst has been used for the preparation of amidines 2 from formimidate 1 through reaction with aromatic amines at room temperature and in good to excellent yields. ...
متن کاملSynthesis of 5-amino-1-aryl-4-cyanoimidazoles from formamidines under solvent-free condition
The aryl-(Z)-N-[2-amino-1,2-dicyanovinyl]formamidine 2 cyclize in solvent-free conditions and in the presence of a base to give a 5-amino-1-aryl-4-cyanoimidazoles 3. Silica sulfuric acid as an efficient and reusable heterogeneous catalyst has been used for the preparation of amidines 2 from formimidate 1 through reaction with aromatic amines at room temperature and in good to excellent yields. ...
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ژورنال
عنوان ژورنال: Chemistry Letters
سال: 1973
ISSN: 0366-7022,1348-0715
DOI: 10.1246/cl.1973.547